PODENTAMIG

UNII:	ZT35532VPU
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	PODENTAMIG
GSRS Full Record:	ZT35532VPU i

2851863-52-8
HPN-217
Immunoglobulin, trispecific, anti-(human tumor necrosis factor receptor superfamily protein TNFRSF17) (human-Lama glama monoclonal HPN217 single-domain VHH fragment) fusion protein with peptide linker (GGGGSGGGS) fusion protein with immunoglobulin anti-(human albumin) (human-Lama glama monoclonal HPN217 single-domain VHH fragment) fusion protein with peptide linker (GGGGSGGGS) fusion protein with immunoglobulin anti-(human CD3 antigen ε-chain) (human-Mus musculus monoclonal HPN217 single-chain variable region fragment VH-(GGGGS)3-VL) fusion protein with hexahistidine tag
Podentamig
immunoglobulin single chain VH-VH'-scFvhl, anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, BCMA, TNFRSF13A, CD269)], anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], trispecific; IG single chain VH-VH'-scFvhl (1-507) [VH anti-TNFRSF17 Vicpac /Homsap (Vicugna pacos IGHV3S53*01 (83.3%) -(IGHD) -IGHJ4*01 (100%)/Homo sapiens IGHV3-23*04 (73.5%) -(IGHD) -IGHJ4*01 (91.7%) L123>Q (114), (CDR-IMGT [8.6.14] (27-33.51-56.95-108)) (1-119) -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (120-128) -VH anti-ALB (Homo sapiens IGHV3-23*04 (88.5%) -(IGHD) -IGHJ1*01 (81.8%) W118>S (333), G119>S (334), CDR-IMGT [8.8.8] (154-161.179-186.225-232)) (129-243) -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (244-252) - scFvhl anti-CD3E (253-507) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (89.9%) -(IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV3-73*01 (85.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (278-285.303-312.351-366)) (253-377) -15-mer-tris(tetraglycyl-seryl) linker (378-392) -V-LAMBDA (Homo sapiens IGLV7-43*01 (86.2%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (418-426.444-446.483-491)) (393-501)] -hexahistidine tag (502-507)], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, lacking the enzyme dihydrofolate reductase (DHFR), non-glycosylated
podentamig [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

PODENTAMIG

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