INTISMERAN AUTOGENE

UNII:	ZG6U44T8SG
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	INTISMERAN AUTOGENE
GSRS Full Record:	ZG6U44T8SG i

2931460-85-2
INTISMERAN AUTOGENE [USAN]
Intismeran Autogene
Intismeran autogene [WHO-DD]
RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Gm)-capped all uridine→N1-methylpseudouridine-substituted patient-specific neoantigen-specifying plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-4157), inner salt
intismeran autogene [INN]
mRNA-4157
messenger RNA (mRNA), 5'-capped, encoding a codon-optimized patient specific concatemer of up to 34 neoantigens designed specifically to each individual patient's tumor mutanome and human leukocyte antigen (HLA) type, further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human hemoglobin subunit alpha (HBA1) gene and terminated by a 3' polyadenylation (polyA) tail; contains N1-methylpseudouridine instead of uridine (all-U>m1Ψ)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

INTISMERAN AUTOGENE

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