ANFLEKITUG

UNII:	ZB82BW7AHP
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ANFLEKITUG
GSRS Full Record:	ZB82BW7AHP i

3031358-45-6
Anflekitug
H-gamma1 heavy chain (1-448) [VH Musmus/Homsap (Mus musculus IGHV1-36*03 (78.6%) -(IGHD) -IGHJ2*01 (100%)/Homo sapiens IGHV1-46*01 (74.5%) -(IGHD) -IGHJ4*01 (84.6%) L123>T (113), V124>L (114), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-213')-disulfide with L-kappa light chain (1'-213') [V-KAPPA Musmus/Homsap (Mus musculus IGKV4-57*01 (83.2%) -IGKJ1*01 (100%)/Homo sapiens IGKV3D-11*02 (76.9%) -IGKJ4*01 (90.9%) V124>L (103'), CDR-IMGT [5.3.9] (27'-31'.49'-51'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (152'), V101 (190')) (107'-213')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Immunoglobulin G1, anti-(human interleukin 1β) (human-Mus musculus monoclonal SSGJ-613 γ1-chain), disulfide with human-Mus musculus monoclonal SSGJ-613 κ-chain, dimer
anflekitug [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens IL1B (interleukin 1 beta, IL-1B, 1L1F2)], monoclonal antibody (anflekitug)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ANFLEKITUG

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