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LIXARKITUG SAMROTECAN

UNII:Z7X4J7N5QF
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:LIXARKITUG SAMROTECAN
GSRS Full Record:
Z7X4J7N5QF
i

  • 3035711-52-2
  • H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-23*01 (92.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-219')-disulfide with L-kappa light chain Homo sapiens (1'-219') [V-KAPPA (Homo sapiens IGKV2-28*01 (98.0%) -IGKJ2*01 (100%), CDR-IMGT [11.3.9] (27'-37'.55'-57'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (158'), V101 (196')) (113'-219')]; dimer (228-228'':231-231'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa; substituted at the eight sulfur atoms of L-cysteinyl residues 222, 228, 231, 219', 222'', 228'', 231'' and 219''' with (3RS)-1-[(2S,5S)-1-{[(9S)-9-ethyl-9-hydroxy-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]amino}-2-methyl-1,4,7,35-tetraoxo-5-(propan-2-yl)-10,13,16,19,22,25,28,31-octaoxa-3,6,34-triazaheptatriacontan-37-yl]-2,5-dioxopyrrolidin-3-yl (samrotecan) groups
  • Immunoglobulin G1, anti-(human interleukin 3 receptor α-chain) (human monoclonal INT-020 γ1-chain), complex with human monoclonal INT-020 κ-chain, dimer, octakis(thioether) with N-[31-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]-L-alaninamide
  • Lixarkitug Samrotecan
  • immunoglobulin G1-kappa, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)], Homo sapiens monoclonal antibody; conjugated on eight cysteinyl residues to samrotecan, comprising a linker and a camptothecin derivative (exatecan)
  • lixarkitug samrotecan [INN]




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