ESONADOGENE IMVOPARVOVEC

UNII:	Z57CL8M2AE
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ESONADOGENE IMVOPARVOVEC
GSRS Full Record:	Z57CL8M2AE i

2678565-23-4
DNA (recombinant replication-defective adeno-associated virus 2 vector NFS01 human cytomegalovirus enhancer plus human cytomegalovirus promoter plus Macacine herpesvirus 3 chimeric intron plus human heme A farnesyltransferase gene COX10 mitochondrial targeting signal peptide fusion with human mitochondria NADH dehydrogenase subunit 4 codon-optimized gene plus heme A farnesyltransferase gene COX10 3′-untranslated region plus simian virus 40 polyadenylation signal plus adeno-associated virus 2 inverted terminal repeat flanks-specifying)
Esonadogene Imvoparvovec
esonadogene imvoparvovec [INN]
recombinant, non-replicating adeno-associated virus serotype 2 (AAV2) vector encoding codon-optimised human NADH dehydrogenase subunit 4 (also known as NADH-ubiquinone oxidoreductase chain 4; MTND4, NADH4, ND4) preceded by a Kozak sequence and a mitochondrial targeting sequence from human heme A: farnesyltransferase cytochrome C oxidase assembly factor (also known as protoheme IX farnesyltransferase, mitochondrial; gene COX10), under control of a human cytomegalovirus enhancer/promoter plus a Macacine herpesvirus-3 chimeric intron, followed with a COX10 gene 3'-untranslated region (UTR), and terminated by a simian virus 40 (SV40) polyadenylation signal, and flanked by AAV2 inverted terminal repeats (ITRs)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ESONADOGENE IMVOPARVOVEC

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