TUPARSTOBART

UNII:	Z0A08C63DF
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	TUPARSTOBART
GSRS Full Record:	Z0A08C63DF i

2649466-03-3
AGEN-2385
AGEN2385
ANTI-LAG-3 MONOCLONAL ANTIBODY INCAGN02385
INCAGN 02385 [WHO-DD]
INCAGN-02385
INCAGN02385
Immunoglobulin G1 [301-alanine,de-C-terminal-lysine], anti-(human lymphocyte activation gene-3 protein) (human-Mus musculus monoclonal INCAGN02385 γ1-chain), disulfide with human-Mus musculus monoclonal INCAGN02385 κ-chain, dimer
TUPARSTOBART [USAN]
Tuparstobart
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-46*02 (80.4%)-(IGHD) -IGHJ4*01 (100%), CDR-IMGT[8.8.14] (26-33.51-58.97-110)) (1-121)-Homo sapiens IGHG1*03, G1m3, nG1m1, G1v29 CH2 A84.4 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 N84.4>A (301) (235-344), CH3 E12 (360), M14 (362) (345-449), CHS K2>del (450))(122-450)], (224-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (86.5%) -IGKJ1*01 (91.7%), CDR-IMGT [7.3.9](27-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01(100%), Km3 A45.1 (154), V101 (192) (109'-215')], dimer (230-230'': 233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, non-glycosylated
immunoglobulin G1-kappa,anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody
tuparstobart [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

TUPARSTOBART

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