POSNAFUSP ALFA

UNII:	YF3FFU3WCF
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	POSNAFUSP ALFA
GSRS Full Record:	YF3FFU3WCF i

2797073-53-9
Immunoglobulin G1 Fab fragment, anti-(human transferrin receptor) (human-Mus musculus monoclonal JR-441 γ1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with human N-sulfoglucosamine sulfohydrolase, disulfide with human-Mus musculus monoclonal JR-441 κ-chain, dimer
Posnafusp Alfa
gamma 1 heavy Fab chain (1-226) [VH (Homo sapiens IGHV5-51*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.9] (31-35.50-66.99-107)) (1-118) -Homo sapiens IGHG1*01 (CH1 (119-226)] fused via peptide linker <sup>227</sup> GGGGSGGGGSGGGGS <sup>241</sup> to N-sulphoglucosamine sulphohydrolase (1-482, 242-723 in the current sequence), residue 291 posttranslationally modified to formylglycine (fGly), (221-219')-disulfide with kappa light chain (1'-219') [V-KAPPA (Homo sapiens IGKV2D-29*02 -IGKJ1*01, CDR-Kabat [16.7.9] (24'-39'.55'-61'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (113'-219')]; non-covalent dimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
humanized immunoglobulin G1-kappa antigen-binding fragment (Fab), anti-[human transferrin receptor 1 (hTfR, p90, CD71)] fused at the C-terminus of the heavy chain via a peptide linker to human N-sulphoglucosamine sulphohydrolase (SGSH, sulfoglucosamine sulfamidase, sulphamidase, EC:3.10.1.1
posnafusp alfa [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

POSNAFUSP ALFA

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