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SACOMITATUG DERUXTECAN

UNII:YC3FM28QGU
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:SACOMITATUG DERUXTECAN
GSRS Full Record:
YC3FM28QGU
i

  • 3055975-39-5
  • H-gamma1 heavy chain humanized (1-447) [VH (Homo sapiens IGHV3-72*01 (85.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.10.8] (26-33.51-60.99-106)) (1-117) -Homo sapiens IGHG1*07 (100%) G1m17, G1m1, G1m2 CH1 K120, CH3 D12, L14, G110 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 D12 (356), L14 (358), G110 (431) (341-445), CHS (446-447)) (118-447)], (220-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV2-28*01 (86.0%) -IGKJ1*01 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atoms of an average of eight L-cysteinyl residues among 220, 226, 229, 219', 220'', 226'', 229'' and 219''' with (3RS)-1-[(10S)-10-benzyl-1-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-1,6,9,12,15,18-hexaoxo-3-oxa-5,8,11,14,17-pentaazatricosan-23-yl]-2,5-dioxopyrrolidin-3-yl (deruxtecan) groups
  • Immunoglobulin G1, anti-(human mucin 1) (human-Mus musculus monoclonal MADP-6301a γ1-chain), complex with human-Mus musculus monoclonal MADP-6301a κ-chain, dimer, octakis(thioether)with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]glycinamide
  • Sacomitatug Deruxtecan
  • immunoglobulin G1-kappa, anti-[Homo sapiens MUC1 (mucin 1, polymorphic epithelial mucin, PEM, CD227)], humanized monoclonal antibody, conjugated on an average of eight cysteinyl residues to deruxtecan, comprising a linker and a camptothecin derivative (sacomitatug deruxtecan)
  • sacomitatug deruxtecan [INN]




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