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TABIRAFUSP ALFA

UNII:Y9CNJ2XD89
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:TABIRAFUSP ALFA
GSRS Full Record:
Y9CNJ2XD89
i

  • 2839527-15-8
  • Human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment containing immunoglobulin-like extracellular domain 2 (103-206, 1-104 in the current sequence) fused to a human vascular endothelial growth factor receptor 2 (VEGFR-2) fragment containing immunoglobulin-like extracellular domain 3 (208-308, 105-205 in the current sequence) fused via peptide linker GGGGSGGGGS (206-215) to the gamma 1 heavy chain of anti-[human interleukin 6 (IL-6)] (216-664) [VH (Homo sapiens IGHV3-23*03 -(IGHD) -IGHJ3*02, CDR-Kabat [5.17.10] (246-250.265-281.314-323)) (216-334) -Homo sapiens IGHG1*03 R431>K (CH1 (335-432), hinge (433-447), CH2 L451>A, L452>A, G454>A (448-557), CH3 L660>C (558-662), CHS (663-664)) (335-664)], (437-213')-disulfide with kappa light chain anti-[human interleukin 6 (IL-6)] (1'-213') [V-KAPPA (Homo sapiens IGKV1-13*02 -IGKJ1*01, CDR-Kabat [10.7.9] (24'-33'.49'-55'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dimer (443-443'':446-446'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa
  • KSI-101 component OG2072 antibody
  • OG-2072
  • OG2072
  • TABIRAFUSP ALFA [USAN]
  • Tabirafusp Alfa
  • Vascular endothelial growth factor receptor 1 (human extracellular immunoglobulin domain 2 fragment) fusion protein with vascular endothelial growth factor receptor 2 (human extracellular immunoglobulin domain 3 fragment) fusion protein with peptide linker ((GGGGS)2) fusion protein with immunoglobulin G1 [236-alanine,237-alanine,239-alanine,445-cysteine] anti-(human interleukin 6) (human monoclonal OG2072 γ1-chain), disulfide with human monoclonal OG2072 κ-chain, dimer
  • tabirafusp alfa [INN]




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