LEPODISIRAN

UNII:	X4BE7S8PN9
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LEPODISIRAN
GSRS Full Record:	X4BE7S8PN9 i

2808361-18-2
LEPODISIRAN [USAN]
LY-3819469 FREE ACID
LY3819469 FREE ACID
Lepodisiran
Lepodisiran [WHO-DD]
RNA, ([4′-de(hydroxymethyl)-4′-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2′-deoxy-2′-fluoro)A-sp-(2′-deoxy-2′-fluoro)G-sp-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)A-Cm-Cm-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-(2′-deoxy-2′-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2′-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2′-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2′-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) (1:1)
duplex of all-P-ambo-4′-de(hydroxymethyl)-4′-[(hydroxymethylphosphinoyl)methoxy]-2′-O-methylthiouridylyl-2′-deoxy-2′-fluorothioadenylyl-(3'→5')-2′-deoxy-2′-fluorothioguanylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-deoxy-2′-fluorouridylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-deoxy-2′-fluoroadenylyl-(3'→5')-2′-O-methyladenylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-deoxy-2′-fluorouridylyl-(3'→5')-2′-O-methyluridylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylguanylyl-(3'→5')-2′-O-methylcytidylyl-(3'→5')-2′-O-methyladenylyl-(3'→5')-2′-O-methylthioadenylyl-(3'→5')-2′-O-methylthioguanylyl-(3'→5')-2′-O-methylguanosine and all-P-ambo-2′-O-methylthiouridylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-deoxy-2′-fluoroguanylyl-(5′→3′)-2′-deoxy-2′-fluorocytidylyl-(5′→3′)-2′-deoxy-2′-fluorouridylyl-(5′→3′)-2′-deoxy-2′-fluorouridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyladenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-{2-[2-{5-[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy]pentanamido}ethoxy)ethoxy]methyl}adenylyl-(5′→3′)-{2-[2-{5-[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy]pentanamido}ethoxy)ethoxy]methyl}adenylyl-(5′→3′)-{2-[2-{5-[(2-acetamido-2-deoxy-b-D-galactopyranosyl)oxy]pentanamido}ethoxy)ethoxy]methyl}adenylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytidylyl-(5′→3′)-2′-O-methyluridylyl-(5′→3′)-2′-O-methylguanylyl-(5′→3′)-2′-O-methylcytosine
lepodisiran [INN]

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LEPODISIRAN

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