ZUNIBERGENE ROCPARVOVEC

UNII:	VFF5C4QV72
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ZUNIBERGENE ROCPARVOVEC
GSRS Full Record:	VFF5C4QV72 i

2856381-73-0
Adeno-associated virus vector 4D-150
DNA (recombinant replication-defective adeno-associated virus vector 4D-150 cytomegalovirus immediate-early enhancer element plus chicken β-actin exon 1 plus intron 1 plus vascular endothelial growth factor C-specific microRNA gene plus chicken β-actin intron 1 fragment plus rabbit β-globin splice acceptor plus synthetic human VEGFR-1-VEGFR-2-IgG1-Fc fusion protein monomer precursor codon-optimized gene plus simian virus 40 polyadenylation signal plus adeno-associated virus 2 inverted terminal repeat flanks-specifying)
Zunibergene Rocparvovec
recombinant non-replicating adeno-associated virus (AAV) vector with a retina-specific capsid variant, encoding a microRNA (miRNA) targeting expression of vascular endothelial growth factor C (VEGF-C) and a codon-optimised fusion protein that consists of VEGF-binding regions derived from the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of human immunoglobulin G1 (the mature expressed protein is equivalent to aflibercept), under control of a synthetic CAG promoter and the simian virus 40 polyadenylation sequence, flanked by AAV2 inverted terminal repeats. The VEGF-C targeting miRNA sequence is located within the chicken beta-actin intron of the CAG promoter
zunibergene rocparvovec [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ZUNIBERGENE ROCPARVOVEC

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