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IXOTATUG VEDOTIN

UNII:V2JQK5RVM3
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:IXOTATUG VEDOTIN
GSRS Full Record:
V2JQK5RVM3
i

  • 3018937-00-0
  • H-gamma1 heavy chain (1-447) [VH Musmus/Homsap (Mus musculus IGHV6-3*01 (88.8%) -(IGHD) -IGHJ2*01 (90.9%) T123>L (112)/Homo sapiens IGHV3-23*03 (82.7%) -(IGHD) -IGHJ5*01 (91.7%) V124>L (113), CDR-IMGT [8.10.8] (26-33.51-60.99-106)) (1-117) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 D12 (356), L14 (358) (341-445), CHS (446-447)) (118-447)], (220-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV12-44*01 (83.2%) -IGKJ1*01 (91.7%) G120>Q (100')/Homo sapiens IGKV1-39*01 (83.2%) -IGKJ2*02 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (226-226'':229-229'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-S, glycoform alfa; substituted at the sulfur atoms of an average of four L-cysteinyl residues among 220, 226, 229, 214', 220'', 226'', 229'' and 214''' with (3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-32-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl (vedotin) groups
  • IXOTATUG VEDOTIN [USAN]
  • Immunoglobulin G1, anti-(human claudin 6) (human monoclonal TORL-1-23 γ1-chain), disulfide with human monoclonal TORL-1-23 κ-chain, dimer, reduced, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
  • Ixotatug Vedotin
  • TORL-1-23 ADC
  • immunoglobulin G1-kappa, anti-[Homo sapiens CLDN6 (claudin 6, claudin-6)], monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker and monomethylauristatin E (MMAE) (ixotatug vedotin)
  • ixotatug vedotin [INN]




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