LONPOVAMERAN

UNII:	UY3ACU236M
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LONPOVAMERAN
GSRS Full Record:	UY3ACU236M i

2972476-18-7
Lonpovameran
RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped Venezuelan equine encephalitis virus nonstructural proteins nsP1, nsP2 [739-leucine], nsP3 [endo-551a-arginine] and nsP4 (RNA-dependent RNA polymerase) codon-optimized transgene plus severe acute respiratory syndrome coronavirus 2 spike glycoprotein [682-glycine,683-serine,685-serine,986-proline,987-proline] omicron XBB.1.5 variant precursor-specifying plus 5′-and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-2319), inner salt
lonpovameran [INN]
mRNA-2319
self-amplifying messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K982P and V983P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein XBB.1.5 variant (derived from GenBank ID: UZG29433.1) containing furin cleavage-inactivating mutations (R678G, R679S and R681S), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail; generation of capped S glycoprotein mRNA is under control of a VEEV subgenomic promoter

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LONPOVAMERAN

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