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RINUMAFUSP ALFA

UNII:UTJ6648D6D
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:RINUMAFUSP ALFA
GSRS Full Record:
UTJ6648D6D
i

  • 3059743-20-0
  • Immunoglobulin G1 [234-phenylalanine,239-alanine,434-alanine], anti-(human epidermal growth factor receptor HER3) (human monoclonal U3-1287 γ1-chain) fusion protein with peptide linker (GGGGS)2 fusion protein with 177-237-neuregulin 1 (human isoform β2 precursor), disulfide with human monoclonal U3-1287 κ-chain, dimer
  • Rinumafusp Alfa
  • human immunoglobulin G1-kappa anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)] fused at the C-terminus of each heavy chain via peptide linker (G 4S)2 to a fragment of human neuregulin 1 (NRG1, acetylcholine receptor-inducing activity protein (ARIA), breast cancer cell differentiation factor p45, glial growth factor, heregulin (HRG), Neu differentiation factor); gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV4-34*01 -(IGHD) - IGHJ2*01, CDR-Kabat [5.16.9] (31-35.50-65.98-106)(1-117) -Homo sapiens IGHG1*03 (CH1 (118-215), hinge (216-230), CH2 L<sup>234</sup>>F, S<sup>239</sup>>A (231-340), CH3 N<sup>434</sup>>A (341-445), CHS (446-447)) (118-447)], fused via peptide linker <sup>448</sup>(GGGGS)<sub>2</sub><sup>457</sup> to human neuregulin 1 fragment (NRG1, acetylcholine receptor-inducing activity protein (ARIA), breast cancer cell differentiation factor p45, glial growth factor, heregulin (HRG), Neu differentiation factor) (177-237, 458-518 in the current sequence), disulfide with kappa light chain (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 -IGKJ1*01, CDR-Kabat [17.7.9] (24'-40'.56'-62'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (114'-220')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO), cell line CHO-K1, glycoform alfa
  • rinumafusp alfa [INN]




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