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TURMETABART ADIZUTECAN

UNII:U9G63L4FA6
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:TURMETABART ADIZUTECAN
GSRS Full Record:
U9G63L4FA6
i

  • 3034205-72-3
  • H-gamma1 heavy chain humanized (1-444) [VH (Homo sapiens IGHV5-51*01 (88.3%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.8] (26-33.51-58.97-104)) (1-115) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 15-G1v37 h S5 (CH1 K120(212) (116-213), hinge 1-15 C5>S (218) (214-228), CH2 (229-338), CH3 D12 (354), L14 (356) (339-443), CHS K2>del (444)) (116-444)], with L-kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV3D-11*02 (87.2%) -IGKJ4*01 (100%), CDR-IMGT [10.3.9] (27'-36'.54'-56'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (157'), V101 (195')) (112'-218')]; dimer (224-224'': 227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atoms of the six L-cysteinyl residues 234, 237, 218', 234'', 237'' and 218''' with 2-{[(2S)-1-{[(2S)-1-({3-[(7S)-7-ethyl-7-hydroxy-8,11-dioxo-7,8,11,13-tetrahydro-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]bicyclo[1.1.1]pentan-1-yl}amino)-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-2-oxoethyl (adizutecan)
  • Immunoglobulin G1 [218-serine,de-445-lysine], anti-(human seizure protein 6 homolog) (human-Mus musculus monoclonal PR-1744211 γ1-chain), complex with human-Mus musculus monoclonal PR-1744211 κ-chain, dimer, 218′′,218′′′,224,224′,227,227′-hexakis(thioether) with N-(2-mercaptoacetyl)-L-valyl-N-[3-[(7S)-7-ethyl-7,8,11,13-tetrahydro-7-hydroxy-8,11-dioxo-10H-1,3-dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-14-yl]bicyclo[1.1.1]pent-1-yl]-L-alaninamide
  • Turmetabart Adizutecan
  • immunoglobulin G1-kappa, anti-[Homo sapiens SEZ6 (seizure related 6 homolog)], humanized monoclonal antibody, conjugated on six cysteinyl residues to adizutecan, comprising a linker and a camptothecin derivative (turmetabart adizutecan)
  • turmetabart adizutecan [INN]




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