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AGAZISIRAN SODIUM

UNII:U8D7GM7K2H
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:AGAZISIRAN SODIUM
GSRS Full Record:
U8D7GM7K2H
i

  • 2985646-80-6
  • ([3′-O-[2-[[[1-[17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-2-oxoethyl]-2′-O-[2-[bis[[1-[17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-2-oxoethyl]]U-(5′→5′)-spGm-sp-Gm-Am-Am-Gm-Gm-Am-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Gm-Am-Um-GmUm-Cm-Um-sp-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]A), complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)A-sp-Gm-(2′-deoxy-2′-fluoro)A-Cm-(2′-deoxy-2′-fluoro)AUm-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)A-Um-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)U-sp-Cm-sp-Cm) sodium salt (1:23:1:21) (1:1)
  • ADX-038 sodium
  • AGAZISIRAN SODIUM [USAN]
  • Agazisiran sodium
  • O-[(2R,3S)-2-(hydroxymethyl)oxolan-3-yl] hydrogen all-P-ambo-3'-O-(2-{[(1-{17-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-3,6,9,12,15-pentaoxaheptadecan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]amino}-2-oxoethyl)-2'-O-(2-{bis[(1-{17-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-3,6,9,12,15-pentaoxaheptadecan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]amino}-2-oxoethyl)-P-thiouridylyl-(5'→5')-2'-O-methyl-Pthioguanylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-Omethyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-Omethyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyl-P-thiouridylyl-(3'→5')-2'-O-methyl-P-thio-3'-adenylate duplex with all-Pambo-2'-O-methyl-P-thiocytidylyl-(5'→3')-2'-O-methyl-P-thiocytidylyl-(5'→3')-2'-deoxy2'-fluorouridylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methyl-P-thioguanylyl-(5'→3')-2'-deoxy-2'-fluoro-Pthioadenylyl-(5'→3')-2'-O-methyluridine sodium salt
  • RNA, ([3′-O-[2-[[[1-[17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-2-oxoethyl]-2′-O-[2-[bis[[1-[17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-2-oxoethyl]]U-(5′→5′)-sp-Gm-sp-Gm-Am-Am-Gm-Gm-Am-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Gm-Gm-Am-Um-Gm-Um-Cm-Um-sp-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]A), sodium salt, complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)A-sp-Gm-(2′-deoxy-2′-fluoro)A-Cm-(2′-deoxy-2′-fluoro)A-Um-(2′-deoxy-2′-fluoro)C-Cm-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)A-Um-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)U-sp-Cm-sp-Cm) sodium salt (1:23:1:21)




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