ACTINIUM AC-225 PELGIFATAMAB POPAXETAN

UNII:	S8KQ6BJU6A
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ACTINIUM AC-225 PELGIFATAMAB POPAXETAN
GSRS Full Record:	S8KQ6BJU6A i

3034630-52-6
Actinium (225Ac) pelgifatamab mopaxetan
Actinium Ac-225 Pelgifatamab Popaxetan
H-gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV3-33*01 (96.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (220) (124-221), hinge 1-15 (222-236), CH2 (237-346), CH3 E12 (362), M14 (364) (347-451), CHS (452-453)) (124-453)], (226-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-27*01 (94.7%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-K1 cell line, glycoform alfa; conjugated via the side chain nitrogen of an average of 0.8 lysine residues to ( 225 Ac)actinium radiolabeled [4-(2-{[2-carboxy-6-({16-[(6-carboxypyridin-2-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl}methyl)pyridin-4-yl]oxy}ethyl)phenyl]carbamothioyl (mopaxetan) groups
Immunoglobulin G1, anti-(human prostate-specific membrane antigen) (human monoclonal TPP-7195 γ1-chain), disulfide with human monoclonal TPP-7195 κ-chain, dimer, N6-[[[4-[2-[[2-(carboxy-κO)-6-[[16-[[6-(carboxy-κO)-2-pyridinyl-κN]methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl-κN7,κN16,κO1,κO4,κO10,κO13]methyl]-4-pyridinyl-κN]oxy]ethyl]phenyl]amino]thioxomethyl]-L-lysine complex with actinium-225Ac
actinium (225Ac) pelgifatamab mopaxetan [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens FOLH1 (folate hydrolase, prostate specific membrane antigen, PSMA)], Homo sapiens monoclonal antibody;conjugated to mopaxetan and radiolabeled with actinium-225

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ACTINIUM AC-225 PELGIFATAMAB POPAXETAN

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