EFSERAKEFUSP ALFA

UNII:	S4NL6N7DWD
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	EFSERAKEFUSP ALFA
GSRS Full Record:	S4NL6N7DWD i

3082221-37-9
Efserakefusp Alfa
IL-15 Super-agonist SHR1501
Interleukin-15 Agonist Fusion Protein SHR1501
Interleukin-15 receptor α chain [40-cysteine] (human sushi domain-containing fragment) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin G1 [5-serine] (human γ-1 chain hinge-CH2-CH3 fragment), disulfide with interleukin-15 [52-cysteine] (human), dimer
SHR-1501
SHR-1501(human Fc fusion protein composed of the cytokine interleukin (IL)-15 cross-linked with the high-affinity binding sushi domain of IL-15 receptor alpha (IL-15Ra))
efserakefusp alfa [INN]
human interleukin-15 receptor subunit alpha (IL-15RA, IL-15R α, CD215; Uniprot: Q13261) sushi domain containing fragment (1-73), variant (S40>C), fused via peptide linker 74GGGGSGGGGS83 to a human immunoglobulin G1 (IgG1) Fc fragment (hinge-CH2-CH3-CHS domains) [Homo sapiens IGHG1*03 (hinge C88>S (84-98), CH2 (99-208), CH3 (209-313), CHS(314-315)) (84-315)], (40-52')-disulfide with human interleukin-15 (IL-15, Uniprot: P40933) (1'-114')), variant (L52'>C); dimer (94-94'', 97-97'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

EFSERAKEFUSP ALFA

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