FDA official logo
GSRS logoPFDA official logo

GIVOSIRAN

UNII:ROV204583W
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:GIVOSIRAN
GSRS Full Record:
ROV204583W
i

  • 1639325-43-1
  • ALN-AS1
  • GIVOSIRAN [MI]
  • GIVOSIRAN [USAN]
  • Givosiran
  • Givosiran [WHO-DD]
  • RNA, (Cm-sp-Am-sp-Gm-Am-Am-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)C-Am-Um-Cm-Um-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- 14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy- -D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa- 13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)G-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)ACm-( 2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'- deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Gm-sp-Gm-sp-Um) (1:1)
  • duplex of [(2S,4R)-1-{1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanamido}propyl)amino]-3- oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-yl]methyl hydrogen (all-P-ambo)-2'-O-methyl-P-thiocytidylyl-(3' 5')- 2'-O-methyl-P-thioadenylyl-(3' 5')-2'-O-methylguanylyl-(3' 5')-2'-O-methyladenylyl- (3' 5')-2'-O-methyladenylyl-(3' 5')-2'-O-methyladenylyl-(3' 5')-2'-deoxy-2'-fluoroguanylyl-(3' 5')-2'-O-methyladenylyl-(3' 5')-2'-deoxy-2'-fluoroguanylyl-(3' 5')-2'- O-methyluridylyl-(3' 5')-2'-deoxy-2'-fluoroguanylyl-(3' 5')-2'-O-methyluridylyl-(3' 5')-2'-deoxy-2'-fluorocytidylyl-(3' 5')-2'-O-methyluridylyl-(3' 5')-2'-deoxy-2'-fluorocytidylyl- (3' 5')-2'-O-methyladenylyl-(3' 5')-2'-O-methyluridylyl-(3' 5')-2'-O-methylcytidylyl-(3' 5')-2'-O-methyluridylyl-(3' 5')-2'-O-methyluridylyl-(3' 5')-2'-O-methyl-3'-adenylate and (all-P-ambo)-2'-O-methyl-P-thiouridylyl-(5' 3')-2'-O-methyl-P-thioguanylyl-(5' 3')- 2'-O-methylguanylyl-(5' 3')-2'-deoxy-2'-fluorouridylyl-(5' 3')-2'-O-methylcytidylyl- (5' 3')-2'-deoxy-2'-fluorouridylyl-(5' 3')-2'-O-methyluridylyl-(5' 3')-2'-deoxy-2'- fluorouridylyl-(5' 3')-2'-O-methylcytidylyl-(5' 3')-2'-deoxy-2'-fluorouridylyl-(5' 3')-2'-Omethylcytidylyl-( 5' 3')-2'-deoxy-2'-fluoroadenylyl-(5' 3')-2'-O-methylcytidylyl-(5' 3')-2'-deoxy-2'-fluoroadenylyl-(5' 3')-2'-O-methylguanylyl-(5' 3')-2'-deoxy-2'-fluoroadenylyl- (5' 3')-2'-O-methylguanylyl-(5' 3')-2'-deoxy-2'-fluorouridylyl-(5' 3')-2'-Omethyladenylyl-( 5' 3')-2'-deoxy-2'-fluoroguanylyl-(5' 3')-2'-deoxy-2'-fluoro-Pthioadenylyl-( 5' 3')-2'-deoxy-2'-fluoro-P-thioadenylyl-(5' 3')-2'-O-methyluridine
  • givosiran [INN]




UNII - ROV204583W | UNII Search Service