REMEMULGENE ARELACTIBAC

UNII:	R2BZ24VRD8
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	REMEMULGENE ARELACTIBAC
GSRS Full Record:	R2BZ24VRD8 i

Rememulgene Arelactibac
non-pathogenic, food-grade lactic acid bacterium Lactococcus cremoris (L. cremoris) strain AUC1000, alr deletion derivative of L. cremoris MG1363, transformed with a plasmid encoding the transgenes for (i) human colony stimulating factor 1 (CSF-1 isoform 3), (ii) human fibroblast growth factor 2 (FGF-2 isoform 3), and (iii) human interleukin 4 (IL-4 isoform-1) whose expression is controlled by a gad operon cassette comprising the gadR regulator gene and a gadCB regulatory region. Each of the three transgenes is optimised for expression in L. cremoris and is coupled to the L. cremoris Usp45 signal sequence preceded by a ribosome binding site derived from the gadC (CSF-1), atpG (FGF-2) and lacA (IL-4) genes of L. cremoris, respectively. The plasmid also contains an alanine racemase (alr) gene for plasmid selection
rememulgene arelactibac [INN]

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

REMEMULGENE ARELACTIBAC

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