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SIGVOTATUG VEDOTIN

UNII:QX0ONY0O9T
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:SIGVOTATUG VEDOTIN
GSRS Full Record:
QX0ONY0O9T
i

  • 2764774-91-4
  • Immunoglobulin G1, anti-(human integrin β6) (human-Mus musculus monoclonal h2A2 γ1-chain), disulfide with human-Mus musculus monoclonal h2A2 κ-chain, dimer, reduced, tetrakis(thioether) with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
  • Immunoglobulin G1-kappa, anti-[Homo sapiens ITGB6 (integrin subunit beta 6)], humanized monoclonal antibody, conjugated on an average of 4 cysteinyl residues via a cleavable linker to monomethylauristatin E (MMAE)
  • Immunoglobulin G1-kappa, anti-[Homo sapiens ITGB6 (integrin subunit beta 6)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV1-46*01 (79.6%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS (445-446)) (117-446)], (219-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (83.2%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa alfa; substituted at the sulfur atoms of four L-cysteinyl residues on average among 219, 225, 228, 214', 219'', 225'', 228'' and 214''' with (3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl (vedotin) groups
  • SGN-B6A
  • SGNB6A
  • SIGVOTATUG VEDOTIN [USAN]
  • Sigvotatug Vedotin
  • Sigvotatug vedotin [WHO-DD]
  • sigvotatug vedotin [INN]




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