PUMITAMIG

UNII:	QEA2EG9S3E
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	PUMITAMIG
GSRS Full Record:	QEA2EG9S3E i

2999726-97-3
BMS-986545
BMS986545
BNT-327
H-gamma1 heavy chain anti-VEGFA fused to a VH anti-CD274 (1-578) [Hgamma1 heavy chain anti-VEGFA humanized (1-452) [VH (Homo sapiens IGHV3-30*02 (76.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.9.16] (26-33.51-59.97-112)) (1-123)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2(CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS K2>del (452) (124-452)] -11-mer bis(tetraglycyl-seryl)-glycyl linker (453-463) -VH anti-CD274 humanized (Homo sapiens IGHV3-74*01 (88.8%) -(IGHD) -IGHJ3*01 (90.0%) W113>K (568), M118>Q (573), CDR-IMGT [8.8.8] (489-496.514-521.560-567)) (464-578)]; (226-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (88.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa
Immunoglobulin G1 [220-lysine,240-alanine,241-alanine,d-C-terminal lysine], anti-(human vascular endothelial growth factor A) (human-Mus musculus monoclonal rhuMAb-VEGF γ1-chain) fusion protein with peptide linker ((GGGS)2G) fusion protein with immunoglobulin, anti-(human programmed death-ligand PD-L1) (human-Lama pacos monoclonal C-Ye-18-5 single-domain VHH fragment), disulfide with human-Mus musculus monoclonal rhuMAb-VEGF κ-chain, dimer
PM-8002
PM8002
PUMITAMIG [USAN]
Pumitamig
Pumitamig [WHO-DD]
immunoglobulin (H-gamma1-VH_L-kappa) dimer, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibody, bispecific, tetravalent (pumitamig)
pumitamig [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

PUMITAMIG

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