EMPASIPRUBART

UNII:	PVA73UA67L
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	EMPASIPRUBART
GSRS Full Record:	PVA73UA67L i

2579031-19-7
ARGX-117
ARGX117
EMPASIPRUBART [USAN]
Empasiprubart
Immunoglobulin G1 [235-alanine,236-alanine,434-lysine,435-phenylalanine], anti-(human complement component 2) (human monoclonal ARGX-117 γ1-chain), disulfide with human monoclonal ARGX-117 κ-chain, dimer
empasiprubart [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens C2 (complement 2)], humanized monoclonal antibody; gamma1 heavy chain humanized (1-447) [VH humanized (Homo sapiens IGHV1-8*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2, G1v46 CH3 K113, F114 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 L1.3>A (235), L1.2>A (236) (232-341), CH3 D12 (357), L14 (359), H113>K (434), N114>F (435) (342-446), CHS K2>del (447)) (119-447)], (221-218')-disulfide with kappa light chain humanized (1'-218') [V-KAPPA (Homo sapiens IGKV4-1*01 (74.3%) -IGKJ2*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (157), V101 (195) (112'-218')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

EMPASIPRUBART

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