CIZUTAMIG

UNII:	P5TLS56PWW
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	CIZUTAMIG
GSRS Full Record:	P5TLS56PWW i

2919209-65-5
CIZUTAMIG [USAN]
Cizutamig
EMB 06 [WHO-DD]
EMB-06
EMB-06-2
EMB06
FIT1006-35b
Immunoglobulin G1, bispecific, anti-(human tumor necrosis factor receptor superfamily protein TNFRSF17) (human-Mus musculus monoclonal EMB-06 κ-chain) fusion protein with immunoglobulin G1 anti-(human CD3 antigen ε-chain) (human-Mus musculus monoclonal EMB-06 γ1-chain), disulfide with human monoclonal EMB-06 κ-chain, dimer, (Cys214→Cys224′′),(Cys214′→Cys224′′′)-bis(disulfide) with immunoglobulin G1 Fab fragment anti-(human tumor necrosis factor receptor superfamily protein TNFRSF17) (human-Mus musculus monoclonal EMB-06 γ1-chain)
cizutamig [INN]
fused L-kappa-H-gamma1 heavy chain anti-TNFRSF17 and anti-CD3E humanized (1-663) [[L-kappa anti-TNFRSF17 humanized (1-214) [V-KAPPA (Homo sapiens IGKV1-39*01 (82.1%) -IGKJ2*02 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153), V101 (191)) (108-214)] -H-gamma1 heavy chain anti-CD3E humanized (215-663) [VH (Homo sapiens IGHV1-2*02 (82.7%) -(IGHD) -IGHJ4*01 (93.3%) L123>T (328), CDR-IMGT [8.8.12] (240-247.265-272.311-322)) (215-333) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, IGHG1v14 CH2 A1.3, A1.2 (CH1 R120>K (430) (334-431), hinge 1-15 (432-446), CH2 L1.3>A (450), L1.2>A (451) (447-556), CH3 E12 (572), M14 (574) (557-661), CHS (662-663)) (334-663)]]; (214-224')-disulfide with VH-G1(CH1-h) light chain anti-TNFRSF17 humanized (1'-224') [VH (Homo sapiens IGHV1-3*03 (84.7%) -IGHD -IGHJ4*01 (92.3%) L123>T (116'), CDR-IMGT [8.8.14] (26'-33'.51'-58'.97'-110')) (1'-121') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120 (CH1 R120>K (218') (122'-219'), hinge 1-5 (220'-224')) (122'-224')]]; (436-219''')-disulfide with L-kappa light chain anti-CD3E humanized (1'''-219''') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.8%) -IGKJ4*01 (100%), CDR-IMGT [12.3.8] (27'''-38'''.56'''-58'''.95'''-102''')) (1'''-112''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (158'''), V101 (196''')) (113'''-219''')]; dimer (442-442'':445-445'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
immunoglobulin [L-kappa-H-gamma1_[VH-G1(CH1-h)]_Lkappa] dimer, anti-[Homo sapiens TNFRSF17 (tumor necrosis factor (TNF) receptor superfamily member 17, B cell maturation antigen, BCMA, TNFRSF13A, CD269)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized monoclonal antibody, bispecific;

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

CIZUTAMIG

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