CIBOTERCEPT

UNII:	NV26E66EB5
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	CIBOTERCEPT
GSRS Full Record:	NV26E66EB5 i

2769700-97-0
2-116-Activin receptor type IIB [12-leucine,28-valine,35-lysine,51-serine,52-leucine,54-isoleucine,70-aspartic acid,71-threonine,76-lysine,90-methionine] (human) fusion protein with peptide linker (GGG) fusion protein with immunoglobulin G1 (human γ1-chain C region C-terminal fragment), dimer
ActRIIB 2.12
CIBOTERCEPT [USAN]
Cibotercept
Cibotercept [WHO-DD]
Human activin receptor type 2-B (activin receptor type IIB, ACTR-IIB) extracellular domain (ECD) fragment (2-116, 1-115 in the current sequence), engineered variant (S1>del, I11>L, L27>V, Q34>K, 50TI51>SL, L53>I, 69QE70>DT, E75>K, F89>M) fused via the peptide linker 116GGG118 to a human immunoglobulin G1 Fc fragment (h-CH2-CH3-CHS domains [Homo sapiens IGHG1*01 (hinge (119-128), CH2 (129-238), CH3 (239-343), CHS K345>del (344-344))]) (119-344), disulfide bridged homodimer, produced in Chinese hamster ovary (CHO) cells, glycoform alf
cibotercept [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

CIBOTERCEPT

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