GAVOCABTAGENE AUTOLEUCEL

UNII:	NP6CFH3G8H
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	GAVOCABTAGENE AUTOLEUCEL
GSRS Full Record:	NP6CFH3G8H i

AUTOLOGOUS T CELLS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ANTI-MESOTHELIN (MSLN) SINGLE-DOMAIN ANTIBODY (SDAB) BASED CHIMERIC ANTIGEN RECEPTOR WITH A LEADER SEQUENCE DERIVED FROM GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR ALPHA (GMCSFR-ALPHA), FUSED TO THE CD3.EPSILON. SUBUNIT OF THE T-CELL RECEPTOR (TCR) VIA AN A3(G4S)3LE FLEXIBLE LINKER, WHICH IS INCORPORATED INTO THE ENDOGENOUS TCR COMPLEX UPON EXPRESSION. THE TRANSGENE IS UNDER CONTROL OF ELONGATION FACTOR-1 ALPHA (EF-1.ALPHA.) PROMOTER ANDWOODCHUCK HEPATITIS VIRUS POST-TRANSCRIPTIONAL REGULATORY ELEMENT. THE VECTOR GENOME ALSO CONTAINS A PACKAGING SIGNAL, A PARTIAL GAGSEQUENCE, A REV RESPONSE ELEMENT (RRE), A CENTRAL POLYPURINE TRACT (CPPT) AND A 3' POLYPURINE TRACT (3'PPT)
GAVOCABTAGENE AUTOLEUCEL [USAN]
Gavocabtagene autoleucel [WHO-DD]
TC-210 T CELLS
gavocabtagene autoleucel [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

GAVOCABTAGENE AUTOLEUCEL

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