TRONTINEMAB

UNII:	N0GBZ1GWC2
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	TRONTINEMAB
GSRS Full Record:	N0GBZ1GWC2 i

2568868-35-7
Immunoglobulin G1 [156-glutamic acid,222-glutamic acid,363-cysteine,375-tryptophan,de-456-lysine], anti-(human β-amyloid 1-40/42) (human clone mAb31 γ1-chain) fusion protein with peptide linker (GGS(GGGGS)3) fusion protein with immunoglobulin anti-(human transferrin receptor 1) (human-Oryctolagus cuniculus clone BBB-1026 heavy chain V-D-J region) fusion protein with immunoglobulin [1-alanine,2-serine] (human κ-chain C region), disulfide with immunoglobulin [endo-111-serine,endo-112-serine] anti-(human transferrin receptor 1) (human-Oryctolagus cuniculus clone BBB-1026 κ-chain V-J region) fusion protein with immunoglobulin G1 (human γ1-chain CH1 region), (235→235'),(238→238'),(358→363')- tris(disulfide) with immunoglobulin G1 [156-glutamic acid,222-glutamic acid,358-cysteine,375-serine,377-alanine,416-valine] anti-(human β-amyloid 1-40/42) (human clone mAb31 γ1-chain), disulfide with immunoglobulin G1 [124-arginine,125-lysine] anti-(human β-amyloid 1-40/42) (human clone mAb31 κ-chain)
RECOMBINANT (2+1) BISPECIFIC HUMANIZED MONOCLONAL ANTI-A-BETA PEPTIDE AND BINDS TO TRANSFERRIN RECEPTOR (TFR).
RG-6102
RG6102
RO-7126209
RO7126209
TRONTINEMAB [USAN]
Trontinemab
immunoglobulin [G1-VH-Ckappa_Vkappa-CH1]_[G1_kappa] with domain crossover, anti-[Homo sapiens APP (amyloid beta, A4 precursor protein) Abeta, conformational epitope 1-40/42)] and anti- [Homo sapiens TFRC (transferrin receptor, p90, CD71)], humanized monoclonal antibody, bispecific; fused chain G1-VH-Ckappa bispecific, anti-APP A beta and anti-TFRC (1-702) [gamma1 heavy chain anti-APP Abeta (1-455) humanized [VH (Homo sapiens IGHV3-23*04 (92.9%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.19] (26-33.51-58.97-115)) (1-126) -Homo sapiens IGHG1*01, G1m17,1, G1v32 CH3 W22 (CH1 K26>E (156), K119>E (222), K120 (223) (127-224), hinge 1-15 (225-239), CH2 (240-349), CH3 S10>C (363), D12 (365), L14 (367), T22>W (375) (350-454), CHS K2>del (455)) (127-455)] -18-mer diglycyl-seryl-tris(tetraglycyl-seryl) linker (456-473) -VH-Ckappa chain anti-TFRC (474-702) humanized [VH (Homo sapiens IGHV4-31*02 (76.0%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.7.19] (498-505.523-529.566-584)) (474-595) -alanylseryl (596-597) -C-KAPPA (Homo sapiens IGKC*01 (100%), Km3 A45.1 (641), V101 (679) (598-702)], (229-215''')-disulfide with kappa light chain anti-APP Abeta (1'''-215''') humanized [V-KAPPA (Homo sapiens IGKV3D-7*01 (89.6%) - IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'''-108''') - Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192), E12>R (124), Q13>K (125) (109'''-215''')], (702-215'''')-disulfide with Vkappa- CH1 chain anti-TFRC (1''''-215'''') humanized [V-KAPPA (Homo sapiens IGKV1-13*02 (94.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.12] (27- 32.50-52.89-100)) (1''''-110'''') -diseryl (111''''-112'''') -CH1-hinge (Homo sapiens IGHG1*01 CH1-h, G1m17 (CH1 K120 (209) (113''''-210''''), hinge 1-5 (211''''-215'''')) (113''''-215'''')], gamma1 heavy chain anti-APP Abeta (1''-456'') humanized [VH (Homo sapiens IGHV3-23*04 (92.9%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.19] (26-33.51-58.97-115)) (1''-126'') -Homo sapiens IGHG1*01, G1m17,1, G1v33 CH3 S22, A24, V86 (CH1 K26>E (156), K119>E (222), K120 (223) (127''-224''), hinge 1-15 (225''-239''), CH2 (240''- 349''), CH3 Y5>C (358), D12 (365), L14 (367), T22>S (375), L24>A (377), Y86>V (416) (350''-454''), CHS (455''-456'')) (127''-456'')], (229''- 215''')-disulfide with kappa light chain anti-APP Abeta (1'''-215''') humanized [V-KAPPA (Homo sapiens IGKV3D-7*01 (89.6%) - IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'''-108''') - Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'''- 215''')], dimer (235-235'':238-238'':363-358'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
trontinemab [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

TRONTINEMAB

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