NUCRESIRAN

UNII:	MCT9H26JQY
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	NUCRESIRAN
GSRS Full Record:	MCT9H26JQY i

2847913-45-3
Nucresiran
RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Um-Am-Am-(2′-deoxy-2′-fluoro)A-Am-Am-Um-Gm-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Um-Cm-Um-Um-Gm-sp-Gm-sp-Um), complex with RNA (Cm-sp-Am-sp-Am-Gm-Am-Gm-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Cm-Am-Um-Um-Um-Um-Um-Am-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)
all-P-ambo-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-Pthioadenylyl-( 3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-Omethyladenylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethyluridylyl-( 3'→5')-2'-O-methyladenylyl-(3'→5')-2'-Omethylcytidylyl-( 3'→5')-3'-O-[{[(2S,4R)-1-{1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanamido}propyl)amino]-3-oxopropoxy}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl}-4-hydroxypyrrolidin-2-yl]methoxy}(hydroxy)phosphoryl]-2'-Omethyluridine duplex with all-P-ambo-2'-O-methyl-P-thiouridylyl-(5'→3')-2'-O-methyl-Pthioguanylyl-( 5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methyl-Pthiouridylyl-( 5'→3')-2'-deoxy-2'-fluoro-P-thioguanylyl-(5'→3')-2'-Omethyladenosine
nucresiran [INN]

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

NUCRESIRAN

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