SEVOLOPRUBART

UNII:	M6YP27CT5Y
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	SEVOLOPRUBART
GSRS Full Record:	M6YP27CT5Y i

2697144-74-2
Immunoglobulin G4 (IgG4)-variant monoclonal antibody (mAb) that has high affinity binding for human CD19, with B cell inhibiting non-depleting function. LY3541860 is composed of two identical IGHV1-69*01 HCs and two identical IGKV3-20*01 LCs. Each HC is made up of 446 amino acids and each LC is made up of 215 amino acids. The heavy chain constant sequence contains an S228P substitution to stabilize against half-antibody formation. The HC N-terminal glutamine exists as pyroglutamate. The HC C-terminal lysine is removed in the coding sequence. Produced in a chinese hamster ovary (CHO) host cell line (CHO K1).
Immunoglobulin G4 [228-proline], anti-(human CD19 antigen) (human monoclonal LY3541860 γ4-chain), disulfide with human monoclonal LY3541860 κ-chain, dimer
LY-3541860
SEVOLOPRUBART [USAN]
Sevoloprubart

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

SEVOLOPRUBART

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