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LUCORAFUSP ALFA

UNII:M55KSH2AGH
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:LUCORAFUSP ALFA
GSRS Full Record:
M55KSH2AGH
i

  • 2769742-99-4
  • AK-130
  • AK130
  • Immunoglobulin G4 [229-proline,235-alanine,236-alanine,476-threonine,de-468-lysine], anti-(human receptor TIGIT) (human-Mus musculus monoclonal AK130 γ4-chain) fusion protein with peptide linker ((GGGGS)4G) fusion protein with 2-137-transforming growth factor β receptor 2 [9-threonine] (human), disulfide with human-Mus musculus monoclonal AK130 κ-chain, dimer
  • Lucorafusp Alfa
  • gamma 4 heavy chain (1-447) [VH (Homo sapiens IGHV4-30-4*01 -(IGHD) -IGHJ4*01, CDR-Kabat [6.16.12] (31-36.51-66.99-110)) (1-121) -Homo sapiens IGHG4*01 (CH1 (122-219), hinge S<sup>229</sup>>P (220-231), CH2 F<sup>235</sup>>A, L<sup>236</sup>>A (232-341), CH3 (342-446), CHS K<sup>448</sup>>del (447)) (122-447)] fused via a (G4S)4 peptide linker (448-467) to human TGF-beta receptor type-2 (TGFR-2, TGFBR2, transforming growth factor-beta receptor type II, TGFβ type II receptor, TGFβRII) extracellular domain fragment 23-159, (1-137 of the mature protein) [T<sup>23</sup>>G<sup>468</sup>, S<sup>31</sup>>T<sup>476</sup>]-variant (468-604 in the current sequence), (135-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ1*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
  • humanized immunoglobulin G4-kappa, anti-[human TIGIT (T cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3)] fused at the C-terminus of the heavy chain, via a (G4S)4 peptide linker, to a fragment of the mature extracellular domain of human TGF-beta receptor type-2, glycoform alfa
  • lucorafusp alfa [INN]




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