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FICERAFUSP ALFA

UNII:LZ88YF62H2
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:FICERAFUSP ALFA
GSRS Full Record:
LZ88YF62H2
i

  • 2764727-44-6
  • BCA 101 [WHO-DD]
  • BCA-101
  • BCA101
  • EGFR/TGFβ Receptor Fusion Protein BCA101
  • FICERAFUSP ALFA [USAN]
  • Ficerafusp Alfa
  • FmAb2
  • Immunoglobulin G1 [de-C-terminal-lysine], anti-(human epidermal growth factor receptor) (human-Mus musculus clone BCA101 γ1-chain), disulfide with human-Mus musculus clone BCA101 κ-chain fusion protein with peptide linker (GGGGS)3 fusion protein with 23-159-transforming growth factor β receptor TGFBR2 (human), dimer
  • chimeric immunoglobulin G1-kappa anti-(human epidermal growth factor receptor) fused at the C-terminus of both light chains, via a (G<sub>4</sub>S)<sub>3</sub> peptide linker, to a fragment of the extracellular domain of human TGF-beta receptor type-2 (TGFR-2, TGF-beta type II receptor, transforming growth factor-beta receptor type II), glycoform alfa
  • ficerafusp alfa [INN]
  • gamma 1 heavy chain (1-448) [VH (Mus musculus IGHV2-2*03 -(IGHD) -IGHJ3*01, CDR-Kabat [5.16.11] (31-35.50-65.98-108)) (1-119) -Homo sapiens IGHG1*08 (CH1 (120-217), hinge (218-232), CH2 (233-342), CH3 (343-447), CHS K <sup>449</sup> >del (448)) (120-448)], (222-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV5-48*01 -IGKJ5*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')] fused via a (G4S) 3 peptide linker (215'-229') to human TGF-beta receptor type-2 (TGFR-2, TGF-beta type II receptor, transforming growth factor-beta receptor type II) extracellular domain fragment 1-137 (230-366 in the current sequence); dimer (228-228'', 231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa




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