RUBRAVAMERAN

UNII:	LEU6C3Q72D
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	RUBRAVAMERAN
GSRS Full Record:	LEU6C3Q72D i

3004804-43-4
RNA (recombinant 5′-[1,2-[m7G-(5′→5′)-ppp-Gm]]-capped all cytidine→5-methylcytidine-substituted Venezuelan equine encephalitis virus nonstructural protein precursor fusion with severe acute respiratory syndrome coronavirus 2 spike glycoprotein XBB.1.5 variant receptor-binding domain fusion with influenza hemagglutinin transmembrane domain plus pan DR-binding epitope codon-optimized transgene plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger VLPC06), inner salt
Rubravameran
rubravameran [INN]
self-amplifying messenger RNA (mRNA), 5'-capped, encoding Venezuelan equine encephalitis virus (VEEV; strain TC-83) RNA-dependent RNA polymerase complex (VEEV non-structural proteins 1-4 [nsP1, nsP2, nsP3 and nsP4]) and a codon-optimised receptor binding domain (RBD) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (Omicron XBB.1.5 variant derived from GenBank ID: OQ054680.1; amino acids 323-527), preceded by the SARS-CoV-2 signal peptide and fused to an H1N1 influenza virus hemagglutinin transmembrane domain and a universal (pan) HLA DR-binding epitope (PADRE), flanked by VEEV 5' and 3' untranslated regions (UTRs) and terminated with a 3' polyadenylation (polyA) tail; contains 5-methylcytosine instead of cytosine (all-C>5mC). Generation of the SARS-CoV-2 RBD mRNA is under control of the VEEV subgenomic promoter

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

RUBRAVAMERAN

Synonyms and Mappings

Resources