CLASEPRUBART

UNII:	LDW8BPL8GB
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	CLASEPRUBART
GSRS Full Record:	LDW8BPL8GB i

2922766-89-8
Claseprubart
Immunoglobulin G4 [40-alanine,77-asparagine,100-glutamic acid,101-asparagine,225-proline,232-glutamic acid,249-tyrosine,251-threonine,253-glutamic acid,de-C-terminal lysine], anti-(human/Macaca fascicularis complement C1s) (human monoclonal DNTH103 γ4-chain), disulfide with recombinant human monoclonal DNTH103 κ-chain, dimer
claseprubart [INN]
immunoglobulin G4-kappa, anti-[Homo sapiens C1S (complement C1s)], Homo sapiens monoclonal antibody (H-gamma4 heavy chain Homo sapiens (1-443) [VH (Homo sapiens IGHV3-11*01 (96.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, 12-G4v5 h P10, 6-G4v3 CH2 E1.2, 9-G4v21 CH2 Y15.1, T16, E18 (CH1 (118-215), hinge 1-12 S10>P (225) (216-227), CH2 L1.2>E (232), M15.1>Y (249), S16>T (251), T18>E (253), L92 (306) (228-337), CH3 (338-442), CHS K2>del (443)) (118-443)], (131-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (95.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (223-223'':226-226'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

CLASEPRUBART

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