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EVRISIRAN

UNII:LDT7DM6RMG
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:EVRISIRAN
GSRS Full Record:
LDT7DM6RMG
i

  • 3110420-82-8
  • Evrisiran
  • O-[(2R,3S)-2-(hydroxymethyl)oxolan-3-yl] hydrogen all-P-ambo-5'-O-({[(2R,3S)-3-{[{[1-(1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-9,13-bis{2-[(2-{2-[(2-acetamido-2-deoxy-β-Dgalactopyranosyl) oxy]ethoxy}ethyl)amino]-2-oxoethyl}-7,14-dioxo-3-oxa-6,9,13-triazaoctadecan-18-oyl)piperidin-4-yl]oxy}(sulfanyl)phosphoryl]oxy}oxolan-2-yl]methoxy}(sulfanyl)phosphoryl)-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-Omethyluridylyl-( 3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-Omethylcytidylyl-( 3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-Omethyluridylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethyladenylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-P-thio-3'-adenylate, duplex with all-P-ambo-2'-O-methyl-P-thioadenylyl-(5'→3')-2'-Omethyl-P-thiocytidylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-Omethyluridylyl-( 5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluoradenylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-Omethyluridylyl-( 5'→3')-2'-O-methylguanylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methyl-P-thioadenylyl-(5'→3')-2'-deoxy-2'-fluoro-(Rp)-P-thioguanylyl-(5'→3')-2'-O-methyluridine
  • RNA, ([1′-de(6-amino-9H-purin-9-yl)]A-(5′→5′)-sp-Um-Gm-Um-Cm-Am-Gm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)A-Cm-Um-Um-Am-Um-Um-Cm-sp-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]A), 3′-[O-[1-[18-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-6,10-bis[2-[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]-2-oxoethyl]-1,5,12-trioxo-16-oxa-6,10,13-triazaoctadec-1-yl]-4-piperidinyl] hydrogen phosphorothioate], complex with RNA (Um-[P(R)]-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Am-Um-Am-(2′-deoxy-2′-fluoro)A-Gm-Um-Gm-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)C-Um-Gm-Am-sp-Cm-sp-Am) (1:1)
  • evrisiran [INN]




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