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AUTOGENE CEVUMERAN

UNII:L8HDH9IB06
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:AUTOGENE CEVUMERAN
GSRS Full Record:
L8HDH9IB06
i

  • 2365453-34-3
  • A 5'-capped single-stranded messenger RNA (mRNA) construct for the expression of patient-specific tumour neoantigens comprising a 5'-cap, a 5'-untranslated region derived from human alpha-globin mRNA, an optimised Kozak sequence, sequences encoding a secretory signal peptide (sec 2.0), transmembrane and cytoplasmic domains of a major histocompatibility complex (MHC) Class I molecule (MITD), a 3'-untranslated region (FI) and a poly(A)-tail; sequences encoding patient specific antigens are inserted between the secretory signal peptide and the transmembrane/cytoplasmic encoding domains
  • AUTOGENE CEVUMERAN [USAN]
  • Autogene cevumeran [WHO-DD]
  • BNT-122
  • BNT122
  • RG 6180
  • RG-6180
  • RNA (recombinant 5′-[1,2-[m7Gm-(5′→5′)-p-[P(R)]-sp-p-G]]-capped 5′-UTR (human α-globin RNA-Kozak)/secretory signal peptide sec2.0-specifying/patient-specific tumor neoantigen-specifying insertion site/major histocompatibility complex class I transmembrane and cytoplasmic domains-specifying/3′-UTR (AES mRNA-mitochondrial 12S rRNA)-containing poly(A)-tailed messenger RO7198457 constant region), inner salt
  • RO-7198457
  • RO7198457
  • autogene cevumeran [INN]




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