LOFACIMIG

UNII:	L55HB62LXD
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LOFACIMIG
GSRS Full Record:	L55HB62LXD i

2857858-76-3
H-gamma1 heavy chain VH-VH-G1(h-CH2-CH3) (1-493) [VH anti-F11 apple 2 domain (Camelus dromedarius IGHV3S45*01 (86.6%)/Homo sapiens IGHV3-66*01 (83.5%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [9.7.23] (26-34.52-58.97-119)) (1-130) -3-mer (glycyl-alanyl-prolyl) linker (131-133) -[VH anti-F11 apple 3 domain (Camelus dromedarius IGHV3S72*01 (81.2%)/Homo sapiens IGHV3-64*04 (79.4%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.20] (159-166.184-190.229-248)) (134-259) -2-mer (glycyl-seryl) linker (260-261) -Homo sapiens IGHG1*01 h-CH2-CH3-CHS G1m17,1 CH3 D12, L14, G1v37 h S5 (hinge 1-15 C5>S(266) (262-276), CH2 (277-386), CH3 D12 (402), L14 (404) (387-491), CHS (492-493)) (262-493)]; dimer (272-272':275-275')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Immunoglobulin, biparatropic, anti-(human coagulation factor XI Apple 2 domain) (human-Lama glama monoclonal KN060 single-domain VHH fragment) fusion protein with peptide linker (GAP) fusion protein with immunoglobulin anti-(human coagulation factor XI Apple 3 domain) (human-Lama glama monoclonal KN060 single-domain VHH fragment) fusion protein with peptide linker(GS) fusion protein with immunoglobulin G1 [5-serine] (human γ1-chain C region C-terminal fragment), dimer
Lofacimig
lofacimig [INN]
only-heavy-chain immunoglobulin VH-VH-G1(h-CH2-CH3) dimer, anti-[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA) apple 2 domain] and anti-[Homo sapiens F11 (coagulation factor XI, FXI, plasma thromboplastin antecedent, PTA) apple 3 domain] humanized monoclonal antibody, bispecific, tetravalent

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LOFACIMIG

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