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PIVEKIMAB SUNIRINE

UNII:L15LO3W1XX
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:PIVEKIMAB SUNIRINE
GSRS Full Record:
L15LO3W1XX
i

  • 2417174-95-7
  • AN ANTIBODY DRUG CONJUGATE CONSISTING OF HUMANIZED ANTI-CD123 ANTIBODY G4723A LINKED WITH DNA ALKYLATING AGENT DGN549C FOR AML AND OTHER CD123-POS. MALIGNANCIES
  • DECNUPAZ
  • HUMANISED IgG1 KAPPA ANTI-CD123 MONOCLONAL ANTIBODY G4723AB - SULFONATED DGN549-C CONJUGATE IMGN632
  • IMGN-632
  • IMGN632
  • IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IL3RA (INTERLEUKIN 3 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN 3 RECEPTOR, ALPHA (LOW AFFINITY), CD123)), MONOCLONAL ANTIBODY, CONJUGATED WITH SULFONATED DGN549-C, A CYTOTOXIC INDOLOBENZODIAZEPINE DIMER BONDED TO A PROTEASE-CLEAVABLE MALEIMIDOETHYLAMINO-ADIPYL-ALA-ALA LINKER; GAMMA1 HEAVY CHAIN (1-450) (VH (HOMO SAPIENS IGHV1-46*01 (80.6%)-(IGHD)-IGHJ4*01 (100%), CDR-IMGT (8.8.14) (26-33.51-58.97-110)) (1-121)-HOMO SAPIENS IGHG1*01, G1M17,1 (CH1 K120 (218) (122-219), HINGE 1-15 (220-234), CH2 (235-344), CH3 D12 (360), L14 (362), S122>C (446) (345-449), CHS K2>DEL (450)) (122-450)), (224-214')-DISULFIDE WITH KAPPA LIGHT CHAIN (1'-214') (V-KAPPA MUSMUS/HOMSAP (MUS MUSCULUS IGKV14-111*01 (83.2%)-IGKJ2*03 (83.3%) S120>Q (100), L124>V (104)/HOMO SAPIENS IGKV1-16*01 (82.1%)-IGKJ2*01 (91.7%) L124>V (104), CDR-IMGT (6.3.9) (27-32.50-52.89-97)) (1'-107')-HOMO SAPIENS IGKC*01 (100%), KM3 A45.1 (153), V101 (191) (108'-214')); DIMER (230-230'':233-233'')-BISDISULFIDE, PRODUCED IN A CHINESE HAMSTER OVARY (CHO)-K1 CELL LINE, GLYCOFORM ALFA; CONJUGATED AT THE SULFUR ATOMS OF CYS446 AND CYS446'' WITH APPROXIMATELY TWO (3.XI.)-1-(2-(6-(((2S)-1-(((2S)-1-(3-((((12S,12AS)-8-METHOXY-6-OXO-12-SULFO-11,12,12A,13-TETRAHYDRO-6H-INDOLO(2,1-C)(1,4)BENZODIAZEPIN-9-YL)OXY)METHYL)-5-((((12AS)-8-METHOXY-6-OXO-11,12,12A,13-TETRAHYDRO-6H-INDOLO(2,1-C)(1,4)BENZODIAZEPIN-9-YL)OXY)METHYL)ANILINO)-1-OXOPROPAN-2-YL)AMINO)-1-OXOPROPAN-2-YL)AMINO)-6-OXOHEXANAMIDO)ETHYL)-2,5-DIOXOPYRROLIDIN-3-YL (SUNIRINE) GROUPS
  • PIVEKIMAB SUNIRINE [USAN]
  • Pivekimab Sunirine-PVZY
  • Pivekimab sunirine [WHO-DD]
  • pivekimab sunirine [INN]




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