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GATUZOSIRAN

UNII:K5P487RKV3
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:GATUZOSIRAN
GSRS Full Record:
K5P487RKV3
i

  • 2409783-34-0
  • GATUZOSIRAN [USAN]
  • GSK4532990A free acid
  • GSK4532990B
  • Gatuzosiran
  • RNA, ([1′-de(6-amino-9H-purin-9-yl)]dA-(5′→5′)-sp-Cm-Gm-Um-Am-Am-Gm-Am-Am-(2′-deoxy-2′-fluoro)G-Um-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)G-Am-Um-Am-Gm-Am-Um-Gm-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]dA), 3′-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2′-deoxy-2′-fluoro)C-sp-Am-sp-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)U-Am-Um-Cm-Am-Gm-(2′-deoxy-2′-fluoro)A-Cm-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-sp-Gm) (1:1)
  • all-P-ambo-[(2R,3S)-2-(hydroxymethyl)oxolan-3-yl] hydrogen 5'-O-({[(2R,3S)-3-({[(cis-4-{(3S,8S)-17-[(2-acetamido-2-deoxy-β-Dgalactopyranosyl) oxy]-3,8-bis[(2-{2-[(2-acetamido-2-deoxy-β-Dgalactopyranosyl) oxy]ethoxy}ethyl)carbamoyl]-6,11-dioxo-15-oxa-2,7,12-triazaheptadecan-1-oyl}cyclohexyl)oxy]hydroxyphosphorothioyl}oxy)oxolan-2-yl]methoxy}hydroxyphosphorothioyl)-2'-O-methylcytidylyl-(3'→5')-2'-Omethylguanylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-Omethyladenylyl-( 3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-Omethyladenylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-O-methyl-P-thio-3'-adenylate duplex with all-P-ambo 2'-O-methyl-P-thioguanylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-Omethylcytidylyl-( 5'→3')-2'-deoxy-2'-fluoro-P-thiouridylyl-(5'→3')-2'-Omethyl-P-thioadenylyl-(5'→3')-2'-deoxy-2'-fluoro-P-thiocytidylyl-(5'→3')-2'-O-methyluridine
  • gatuzosiran [INN]




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