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RELMACABTAGENE AUTOLEUCEL

UNII:K5CXA4X5U8
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:RELMACABTAGENE AUTOLEUCEL
GSRS Full Record:
K5CXA4X5U8
i

  • AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) TRANSDUCED WITH A NONREPLICATIVE SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING OF THE HUMAN CD19-SPECIFIC SCFV, AN LGG4 HINGE REGION, CD28 TRANSMEMBRANE DOMAIN, CD137 (4-1BB) CO-STIMULATORY DOMAIN AND CD3 ZETA SIGNALLING DOMAIN, UNDER THE CONTROL OF A HYBRID ELONGATION FACTOR 1 ALPHA (EF1.ALPHA.) AND HUMAN T CELL LEUKEMIA VIRUS TYPE 1(HTLV-1) REGULATORY ELEMENT PROMOTER AND WOODCHUCK HEPATITIS VIRUS POST-TRANSCRIPTIONAL REGULATORY ELEMENT (WPRE). THE VECTOR GENOME ALSO ENCODES A TRUNCATED HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFRT) THAT IS CO-EXPRESSED WITH THE CAR AND CLEAVED FROM IT BY THE T2A SELF-CLEAVING PEPTIDE. THE VECTOR GENOME ALSO CONTAINS A SPLICE DONOR, A FRAGMENT OF GAG, A REV RESPONSE ELEMENT (RRE), A MUTATED CENTRAL POLYPURINE TRACT (CPPT), AND A SPLICE ACCEPTOR
  • Carteyva
  • JWCAR-029
  • Relmacabtagene autoleucel [WHO-DD]
  • relma-cel
  • relmacabtagene autoleucel [INN]




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