ZAPOMERAN

UNII:	J9E7RSF8K3
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ZAPOMERAN
GSRS Full Record:	J9E7RSF8K3 i

2727965-96-8
RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped Venezuelan equine encephalitis virus RNA-dependent RNA polymerase codon-optimized transgene plus severe acute respiratory syndrome coronavirus 2 spike pre-fusion glycoprotein [614-glycine,682-glycine,683-serine,685-serine,986-proline,987-proline] precursor-specifying plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-2105), inner salt
Zapomeran
mRNA-2105
self-replicating messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K986P and V987P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (derived from GenBank ID YP_009724390) containing furin cleavage-inactivating mutations (R682G, R683S,R685S) plus an additional mutation (D614G), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail and generation of the capped S mRNA is under control of a VEEV subgenomic promoter.
zapomeran [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ZAPOMERAN

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