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ZAPOMERAN

UNII:J9E7RSF8K3
Formula:
Preferred Substance Name:ZAPOMERAN

  • 2727965-96-8
  • MRNA-2105
  • RNA (RECOMBINANT 5'-(M7G-(5'->5')-PPP-AM)-CAPPED VENEZUELAN EQUINE ENCEPHALITIS VIRUS RNA-DEPENDENT RNA POLYMERASE CODON-OPTIMIZED TRANSGENE PLUS SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE PRE-FUSION GLYCOPROTEIN (614-GLYCINE,682-GLYCINE,683-SERINE,685-SERINE,986-PROLINE,987-PROLINE) PRECURSOR-SPECIFYING PLUS 5'- AND 3'-UNTRANSLATED FLANKING REGION-CONTAINING POLY(A)-TAILED MESSENGER MRNA-2105), INNER SALT
  • SELF-REPLICATING MESSENGER RNA (MRNA), 5'-CAPPED, ENCODING CODON-OPTIMISED VENEZUELAN EQUINE ENCEPHALITIS VIRUS (VEEV) RNA-DEPENDENT RNA POLYMERASE (VEEV PROTEINS NSP1, NSP2, NSP3 AND NSP4) AND A FULL-LENGTH CODON-OPTIMISED PRE-FUSION STABILISED CONFORMATION VARIANT (K986P AND V987P) OF THE SARS-COV-2 (SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2) SPIKE (S) GLYCOPROTEIN (DERIVED FROM GENBANK ID YP_009724390) CONTAINING FURIN CLEAVAGE-INACTIVATING MUTATIONS (R682G, R683S,R685S) PLUS AN ADDITIONAL MUTATION (D614G), FLANKED BY 5' AND 3' UNTRANSLATED REGIONS AND A 3' POLYADENYLATION (POLYA) TAIL AND GENERATION OF THE CAPPED S MRNA IS UNDER CONTROL OF A VEEV SUBGENOMIC PROMOTER.
  • ZAPOMERAN [INN]




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