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BEMREMERAN

UNII:J87X96APT2
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:BEMREMERAN
GSRS Full Record:
J87X96APT2
i

  • 2931519-21-8
  • Bemremeran
  • RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped severe acute respiratory syndrome coronavirus 2 XBB.1.5 variant (1-13)-(315-537)-spike glycoprotein precursor [534-serine] plus human β-globin 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger DS05243268), inner salt
  • bemremeran [INN]
  • messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein (Omicron variant XBB.1.5; based upon GISAID EPI_ISL_16433058), with a cysteine to serine substitution at residue 233 (corresponding to cys534 in the full-length spike glycoprotein), expressed as a fusion protein with the S glycoprotein signal peptide derived from SARS-CoV-2 Wuhan-Hu 1 strain (GenBank: MN908947.3), flanked by 5' and 3' untranslated regions (UTRs) derived from the human β-globin gene and a 3' polyadenylation (polyA) tail; contains 5-methyluridine instead of uridine (all-U>5-Me-U) and 5-methylcytidine instead of cytidine (all-C>5-Me-C)




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