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EMERFETAMAB

UNII:HOG226RYH1
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:EMERFETAMAB
GSRS Full Record:
HOG226RYH1
i

  • 2250261-27-7
  • AMG-673
  • EMERFETAMAB [USAN]
  • IMMUNOGLOBULIN SCFV-SCFV-SCFC, ANTI-(HOMO SAPIENS CD33 (SIALIC ACID BINDING IG-LIKE LECTIN 3, SIGLEC3, SIGLEC-3, GP67, P67)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), MONOCLONAL ANTIBODY SINGLE CHAIN (SCFV)2-SCFC, BISPECIFIC; IG SCFV-SCFV-SCFC SINGLE CHAIN, ANTI-CD33 AND ANTI-CD3E (1-993) (SCFV-VH-V-KAPPA ANTI-CD33 (1-250) (VH (HOMO SAPIENS IGHV1-18*01 G49>C (44) (81.6%)-(IGHD)-IGHJ4*01 (93.3%)) CDR-IMGT (8.8.15) (26-33.51-58.97-111) (1-122)-15-MER TRIS(TETRAGLYCYL-SERYL) LINKER (123-137)-V-KAPPA (HOMO SAPIENS IGKV4-1*01 (83.2%)-IGKJ5*01 Q120>C (243) (91.7%)) CDR-IMGT (12.3.9) (164-175.193-195.232-240) (138-250))-6-MER SERYL-TETRAGLYCYL-SERYL LINKER (251-256)-SCFV-VH-V-LAMBDA ANTI-CD3E (257-505) (VH (MUS MUSCULUS IGHV10-1*02 (91.9%)-(IGHD)-IGHJ3*01 (86.7%)/HOMO SAPIENS IGHV3-73*01 (87%)-(IGHD)-IGHJ5*01 (100%)) CDR-IMGT (8.10.16) (282-289.307-316.355-370) (257-381)-15-MER TRIS(TETRAGLYCYL-SERYL) LINKER (382-396)-V-LAMBDA (HOMO SAPIENS IGLV7-43*01 (85.1%)-IGLJ3*02 (100%)) CDR-IMGT (9.3.9) (422-430.448-450.487-495) (397-505))-4-MER TETRAGLYCYL LINKER (506-509)-SCFC (H-CH2-CH3)-(H-CH2-CH3) (510-993) (HOMO SAPIENS IGHG1*03 H-CH2-CH3, NG1M1 (HINGE 6-15 (510-519), CH2 R83>C (581), N84.4>G (586), V85>C (591) (520-629), CH3 E12 (645), M14 (647) (630-734), CHS (735-736)) (510-736)-30-MER HEXAKIS(TETRAGLYCYL-SERYL) LINKER (737-766)-HOMO SAPIENS IGHG1*03 H-CH2-CH3, NG1M1 (HINGE 6-15 (767-776), CH2 R83>C (838), N84.4>G (843), V85>C (848) (777-886), CH3 E12 (902), M14 (904) (887-991), CHS (992-993)) (767-993))), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, NON-GLYCOSYLATED
  • IMMUNOGLOBULIN, ANTI-(HUMAN SIALIC ACID-BINDING IG-LIKE LECTIN 3) (HUMAN MONOCLONAL 1837MNGSSMABC SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN ANTI-(HUMAN CD3 ANTIGEN .EPSILON.-CHAIN) (HUMAN MONOCLONAL 1837MNGSSMABC SINGLE-CHAIN VARIABLE FRAGMENT VH2-(GGGGS)3-VL2) FUSION PROTEIN WITH FUSION PROTEIN WITH PEPTIDE LINKER (GGGG) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C-REGION C-TERMINAL FRAGMENT) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS)6 FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C-REGION C-TERMINAL FRAGMENT)
  • emerfetamab [INN]




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