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AMULIRAFUSP ALFA

UNII:HFR7WU5YK7
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:AMULIRAFUSP ALFA
GSRS Full Record:
HFR7WU5YK7
i

  • 2850355-94-9
  • 1-133-Signal regulatory protein α [80-alanine] (human isoform 4 variant) fusion protein with peptide linker ((GGGGS)2) fusion protein with immunoglobulin G1 [445-alanine,530-alanine,531-alanine] anti-(human CD20 antigen) (human-Mus musculus monoclonal IMM0306 γ1-chain) disulfide with human-Mus musculus monoclonal IMM0306 κ-chain, dimer
  • Amulirafusp alfa
  • Human signal regulatory protein alpha (SIRP alpha variant V2 extracellular D1 domain, SIRP alpha V2D1) fragment 31-163, comprising the first two extracellular loops of the D1 domain, [N<sup>110</sup>>A<sup>80</sup>]-variant, anti-(human CD47, integrin associated protein (IAP)) (1-133 in the current sequence) fused via a (G4S) 2 peptide linker (134-143) to gamma 1 heavy chain (144-594) [VH (Mus musculus IGHV1-12*01 -(IGHD) -IGHJ1*01, CDR-Kabat [5.17.12](174-178.193-209.242-253)) (144-264) -Homo sapiens IGHG1*03(CH1 (265-362), hinge (363-377), CH2 S<sup>445</sup>>A, E<sup>480</sup>>A, K <sup>481</sup>>A (378-487), CH3 (488-592), CHS (593-594)) (265-594)], (367-213')-disulfide with kappa light chain (1'-213') [V-KAPPA (Mus musculus IGKV4-72*01 -IGKJ1*01, CDR-Kabat [10.7.9] (24'-33'.49'-55'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dimer (373-373'':376-376'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
  • Human signal regulatory protein alpha (SIRPα) fragment, anti-(human CD47, integrin associated protein (IAP)), fused via a (G<sup>4</sup>>S)<sup>2</sup>peptide linker to the N-terminus of both heavy chains of a chimeric immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD20), glycoform alfa
  • IMM 0306 [WHO-DD]
  • IMM-0306
  • IMM0306
  • IMM0306 (BISPECIFIC ANTIBODY-TRAP SELECTIVELY TARGETING CD47 AND CD20)
  • amulirafusp alfa [INN]




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