LECOMKAFUSP ALFA

UNII:	HA9RQB7ML6
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LECOMKAFUSP ALFA
GSRS Full Record:	HA9RQB7ML6 i

3037532-60-5
INDUKINE, (WTX-124)-
Interleukin 2 (human) fusion protein with protease-cleavable peptide linker (synthetic 15-amino acid) fusion protein with immunoglobulin, anti-(human/Mus musculus/Rattus norvegicus/Cavia porcellus/Macaca fascicularis albumin) (human-Lama glama monoclonal 10GE single-domain VHH fragment) fusion protein with protease-cleavable peptide linker (synthetic 45-amino acid) fusion protein with immunoglobulin G1, anti-(human interleukin 2) (human-Mus musculus monoclonal VHVL.F2.high.A02_A46S γ1-chain VH-CH1 region), disulfide with human-Mus musculus monoclonal VHVL.F2.high.A02_A46S κ-chain
Lecomkafusp Alfa
human interleukin-2 (IL-2, IL2; Uniprot: P60568) (1-133), fused via a protease cleavable peptide linker 134<s/up>SGGPALFKSSFPPGS148 to a humanized single-domain VHH fragment anti-(human albumin, serum albumin, HSA (ALB)) (149-263) [VH (Homo sapiens IGHV3-23*04 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.6] (179-183.198-214.247-252))], fused at the C-terminus via peptide linker 264(G4S) 6SGGPALFKSSFPPGS308 to humanized immunoglobulin G1-kappa antigen-binding (Fab) fragment anti-(human interleukin-2, IL-2, T-cell growth factor, TCGF (IL2)) (309-528) [VH (Homo sapiens IGHV3-48*01 -(IGHD) -IGHJ3*01, CDR-Kabat [5.16.9] (339-343.358-373.406-414)) (309-425) -Homo sapiens IGHG1*03 (CH1 (426-523), hinge DKTHTCPPCP 529>del (524-528))]-disulfide with humanized kappa light chain anti-(human interleukin-2, IL-2, T-cell growth factor, TCGF (IL2)) (1'-214') [V-KAPPA (Homo sapiens IGKV1D-16*02 -IGKJ4*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (528-214')-disulfide; produced Chinese hamster ovary (CHO) cells, cell line CHO-K1SV GS-KO
lecomkafusp alfa [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LECOMKAFUSP ALFA

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