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VISLARAFUSP ALFA

UNII:GTN7CK8Y7C
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:VISLARAFUSP ALFA
GSRS Full Record:
GTN7CK8Y7C
i

  • 2850355-96-1
  • IMM-2902
  • IMM2902
  • Immunoglobulin G1 [351-alanine,386-alanine,387-alanine] anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal IMM2902 γ1-chain), disulfide with 1-125-signal regulatory protein α [80-alanine] (human isoform 4 variant) fusion protein with peptide linker ((GGGGS)3) fusion protein with human-Mus musculus monoclonal IMM2902 κ-chain, dimer
  • Vislarafusp Alfa
  • gamma 1 heavy chain (1-450) [VH (Homo sapiens IGHV3-66*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.11] (31-35.50-66.99-109)) (1-120) -Homo sapiens IGHG1*03 (CH1 (121-218), hinge (219-233), CH2 S<sup>301</sup>>A, E<sup>336</sup>>A, K<sup>337</sup>>A (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-354')-disulfide with human signal regulatory protein alpha (SIRP alpha variant V2 extracellular D1 domain, SIRP alpha V2D1) fragment (1-125), comprising the first two extracellular loops of the D1 domain, engineered variant [N<sup>80</sup>>A]-variant, anti-(human CD47, integrin associated protein (IAP)) (1-125 in the current sequence) fused via a (G4S)3peptide linker (126-140) to kappa light chain (141'-354') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ1*01, CDR-Kabat [11.7.9] (164'-174'.190'-196'.229'-237')) (141'-247') -Homo sapiens IGKC*01 (248'-354')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
  • human signal regulatory protein alpha (SIRPα) fragment, anti-(human CD47, integrin associated protein (IAP)), fused via a (G4S)3 peptide linker to the N-terminus of both light chains of a humanized immunoglobulin G1-kappa anti-(human epidermal growth factor receptor 2), glycoform alfa
  • vislarafusp alfa [INN]




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