DATOPOTAMAB DERUXTECAN

UNII:	GD2OWY1DTK
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	DATOPOTAMAB DERUXTECAN
GSRS Full Record:	GD2OWY1DTK i

2238831-60-0
ANTI-TROP2/DXD ANTIBODY-DRUG CONJUGATE DS-1062A
DATO-DXD
DATOPOTAMAB DERUXTECAN [USAN]
DATROWAY
DS-1062
DS-1062A
DS1062
Datopotamab Deruxtecan
Datopotamab Deruxtecan-DLNK
Datopotamab deruxtecan [WHO-DD]
Datopotamab deruxtecan dlnk [WHO-DD]
Immunoglobulin G1, anti-(human tumor-associated calcium signal transducer 2) (human-Mus musculus monoclonal MAAP-9001 γ1-chain), compd. with human-Mus musculus monoclonal MAAP-9001 κ-chain, dimer, thioether with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]glycinamide
datopotamab deruxtecan [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2)], humanized monoclonal antibody conjugated to deruxtecan, comprising a linker and a camptothecin derivative; gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-3*01(79.6%) -(IGHD) - IGHJ4*01 (93.3%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)], (224-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (84.2%) -IGKJ2*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (230-230'':233-233'')-bisdisulfide; produced in Chinese hamster ovary (CHO) cells, glycoform alfa, conjugated, on an average of 4 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

DATOPOTAMAB DERUXTECAN

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