SOLIZMESTROCEL

UNII:	G64F59W88V
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	SOLIZMESTROCEL
GSRS Full Record:	G64F59W88V i

ALLOGENEIC HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS
ALLOGENEIC HUMAN UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS (HUC-MSCS)
ALLOGENIC HUMAN MESENCHYMAL STEM CELLS (MSCS) DERIVED FROM UMBILICAL CORD TISSUE
HUC-MSCS
Human Umbilical Cord Mesenchymal Stem Cells
Solizmestrocel
UC-MSC
UMC-119-06
UMC119-01
UMC119-06
UMC119-06-05
UMSC-01
UMSC01
XytriX
YB-1113
allogeneic mesenchymal stromal cells (MSC) derived from genetically selected umbilical cord tissue. The cord tissue is enzymatically digested, and the cells cultured in a xeno-free medium supplemented with human platelet lysate. The cells are positive (>90%) for the mesenchymal stromal cell surface markers CD105+, CD73+, CD90+, and are negative (<10%) for CD45-, CD34-, CD19-, CD11b-, and HLA-DR-. The cells release anti-fibrotic molecules such as matrix metalloproteinase-1 (MMP-1) and microRNA-29c (miR-29c). The cells also inhibit T lymphocyte proliferation upon CD3/CD28/CD2 activation, suppress tumor necrosis factor alpha (TNFα) secretion of immune cells (peripheral blood mononuclear cells /macrophages) upon lipopolysaccharides (LPS) stimulation, and upregulate soluble TNF receptor 1 and 2 secretion upon TNFα/interferon gamma (IFN-γ) stimulation
solizmestrocel [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

SOLIZMESTROCEL

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