ROLTOTATUG

UNII:	FRJ2K868QN
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ROLTOTATUG
GSRS Full Record:	FRJ2K868QN i

3038456-05-9
H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV4-4*08 (85.6%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [8.7.12] (26-33.51-57.96-107)) (1-118) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-220')-disulfide with L-kappa light chain humanized (1'-220') [V-KAPPA(Homo sapiens IGKV4-1*01 (90.1%) -IGKJ2*01 (100%), CDR -IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (227-227'':230-230'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa
Immunoglobulin G1, anti-(human notch ligand DLK1) (human-Mus musculus monoclonal TORL-4-500 γ1-chain), disulfide with human-Mus musculus monoclonal TORL-4-500 κ-chain, dimer
Roltotatug
TORL-4-500 mAb
immunoglobulin G1-kappa, anti-[Homo sapiens DLK1 (delta like non-canonical Notch ligand 1)], humanized monoclonal antibody (roltotatug)
roltotatug [INN]

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ROLTOTATUG

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