EBRIBAFUSP ALFA

UNII:	FR7T6AM49L
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	EBRIBAFUSP ALFA
GSRS Full Record:	FR7T6AM49L i

2839652-75-2
ADX-097
EBRIBAFUSP ALFA [USAN]
Ebribafusp Alfa
Immunoglobulin G4 [219-proline,226-glutamic acid,419-leucine,425-serine,de-438-lysine], anti-(human complement C3d) (human-Mus musculus monoclonal ADX-097 γ4-chain) fusion protein with peptide linker ((GGGGS)2) fusion protein with 19-323-complement factor H (human), disulfide with human-Mus musculus monoclonal ADX-097 κ-chain, dimer
ebribafusp alfa [INN]
gamma 4 heavy chain (1-437) [VH (Homo sapiens IGHV1-46*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.2] (31-35.50-66.99-100)) (1-111) -Homo sapiens IGHG4*01 (CH1 (112-209), hinge S 219>P (210-221), CH2 L 226>E(222-331), CH3 M 419>L, N 425>S (332-436), CHS K 438>del (437)) (112-437)]fused via a (G4S) 2 peptide linker (438-447) to human complement factor H fragment 1-305 (448-752 in the current sequence, containing the first five consensus repeat Sushi domains, residues 1_304, plus the adjacent K 305),(125-219')-disulfide with kappa light chain (1'-219') [V-KAPPA (Homo sapiens IGKV2-30*01 -IGKJ4*01, CDR-Kabat [16.7.9] (24'-39'.55'-61'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (113'-219')]; dimer (217-217'':220-220'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-M, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

EBRIBAFUSP ALFA

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