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MELREDABLEUKIN ALFA

UNII:FAA3D9E2LP
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:MELREDABLEUKIN ALFA
GSRS Full Record:
FAA3D9E2LP
i

  • 2056881-92-4
  • Immunoglobulin G1, (human monoclonal γ1-chain) fusion protein with peptide (synthetic linker) fusion protein with interleukin 2 (synthetic human mutein), disulfide with human monoclonal κ-chain, dimer
  • MELREDABLEUKIN ALFA [USAN]
  • RG-7835
  • RG7835
  • RO-7049665
  • RO7049665
  • human immunoglobulin G1 non-binding variant (heavy chain 1-444, L232>A, L233>A, P327>G) fused at the C-terminus of the heavy chain via peptidyl linker 445GGGGSGGGGSGGGGS459 to human interleukin 2 (1-133, 460- 592 in the current sequence) variant (T3 >A462, N88>D547, C125>A584), dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; human non-binding immunoglobulin G1 kappa (IgG1-κ) fused via a peptide linker to a mutated human interleukin 2 (IL2 mutein): fusion protein combining a gamma1 heavy chain (1-444) [Homo sapiens IGHV3-23*01; Homo sapiens IGHJ4*01; Homo sapiens IGHG1*01; VH: 1-115; CH1: 116-213; hinge: 214-228; CH2: 229-338 (L232>A, L233>A, P327>G); CH3: 339-443; CHS: 444-444 (K445del); CDR Kabat H1: SYAMS (31-35); CDR Kabat H2: AISGSGGSTYYADSVKG (50-66); CDR Kabat H3: GSGFDY (99- 104)], a (G4S)3 peptide linker (445-459), and Homo sapiens interleukin 2 (460-592) [T3 >A462, N88>D547, C125>A584]-variant, (218- 215')-disulfide with kappa light chain (1'-215') [Homo sapiens IGKV3-20*01; Homo sapiens IGKJ1*01; Homo sapiens IGKC*01; VL: 1-108; CL: 109-215; CDR Kabat L1: RASQSVSSSYLA (24-35); CDR Kabat L2: GASSRAT (51-57); CDR Kabat L3: QQYGSSPLT (90-98)]; dimer (224-224":227-227")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
  • melredableukin alfa [INN]




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